“Men with prostate cancer who are initiating ADT have a 5- to 10-fold increased loss of bone density at multiple skeletal sites.” They also lose lean body mass and gain fatty tissue.

Men taking anti-androgen drug therapy to suppress their male hormones are at risk for loss of bone mineral density (BMD) . This puts the men at risk of fractures including of rib, spinal, and/or hip. Until recently, no information was available to patients from the drug manufacturers nor from doctors about how soon after starting after starting on androgen blockade this condition is likely to start.
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Forbes has a story this month about a Cox-II inhibitor, Celebrex. While mostly used for arthritis pain, this drug is of high interest to cancer patients as a possible tumor inhibitor (for background on the cancer connection see
Cancer Patients … and Celebrex in Anti-Cancer Trials Nov 2004
(full story…)