Prostate Cancer May Result from Chronic Inflammation, Study Says

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Prostate Cancer May Result from Chronic Inflammation April 8, 2002 /Johns Hopkins/ The earliest stages of prostate cancer may develop in lesions generally associated with chronic inflammation and might be reversible with anti-inflammatory drugs and dietary supplements, new research suggests. Hopkins Kimmel Cancer Center researchers screened several stages of normal and cancerous prostate cells for changes in a key gene, called glutathione S-transferase p (GSTP1). Glutathione S-transferase p (GSTP1) detoxifies environmental carcinogens and protects against cancer. In prostate cancer, this gene is deactivated through a biochemical process known as hypermethylatio Methylation acts like the safety on a gun, causing a gene to stop working. Too much or "hyper"methylation on the GSTP1 gene shuts off its cancer-preventing properties as the prostate stops producing critical protective enzymes. Hopkins Kimmel Cancer Center researchers looked at GSTP1 hypermethylation in normal and prostate cancers tissue samples as well as in inflammatory prostate lesions known as PIA (proliferative inflammatory atrophy) and PIN (prostate intraepithelial neoplasia). They found GSTP1 methylation in three of 17 (17.6 percent) of PIA lesions, six of ten (60 percent) of high-grade PIN lesions and seven of seven (100 percent) prostate cancers. No GSTP1 methylation was detected in seven samples of normal prostate tissue. The increasing levels of GSTP1 methylation may show how prostate cancer develops. The starting point may be PIA lesions, which are associated with inflammation and produce high levels of the GSTP1 gene suggesting that the gene has kicked into high gear from some kind of environmental stress. It is in these PIA lesions that researchers believe the first genetic mistakes are made leading to hypermethylation of the GSTP1 gene leaving prostate cells unable to repair damage from carcinogens. With an onslaught of carcinogens from the environment and diet, researchers believe more gene mistakes are made, making PIA lesions progress to PIN lesions, funny-looking cells strongly linked to cancer and considered by some to be pre-cancerous. Investigators will test the prostate cancer preventive effects of anti-inflammatory agents and antioxidant nutrients on PIA lesions in animal models. advertisement	Preventing prostate cancer PSA and DRE to detect prostate cancer Flowchart for evaluating raised PSA PSA-f may spare you a biopsy More about PSA Biopsy basics Prostate cancer staging I've been diagnosed, what now? Recent News Chronic Inflammation Linked With Start of Prostate Cancer: A 5 Year Follow Up Study April 2006 Benefit of PSA test, prostate cancer screening falls for older men Nov 25 2005 Sunshine protects men against prostate cancer June 2005 High-risk Prostate Cancer Can Be Predicted Without A Biopsy June 2005 Brothers at high risk for prostate cancer. Sept 2, 2004 PSA tests from age 35 needed to track or speed of rise; 2 points or more in one year suggests aggressive disease July 15, 2004 Men with "high grade PIN" are at risk for invasive prostate cancer, study finds Oct 19 2004 New drug aimed at men diagnosed with High Grade PIN Oct 19 2004 Common urinary tract virus linked to prostate cancer August 2004 Prostate cancer rate lower in men taking dutasteride for BPH Urology, Washington University School of Medicine, St. Louis (abstract) 04-10-15 Use of aspirin or other NSAIDs increases survival for men with prostate cancer. Oct 2004 Obesity Linked to More Aggressive Prostate Cancer Dec 23, 2003 Heavy Smoking Doubles Risk of Aggressive Prostate Cancer August 1, 2003. Infections and cancer risk "In the United States and other developed countries, approximately 7 per cent of all cancers have been linked to infections. In developing countries, this number reaches almost 25 percent." Harvard School of Public Health, 2003/2004 We subscribe to the HONcode principles. Verify here.
About Us \| Content Policy/Disclaimer \| Your Privacy © 1997-2005 PSA Rising This page last edited by J. Strax, Cecember 26, 2005. Information on this website is not intended as medical advice nor to be taken as such. Consult qualified physicians specializing in the treatment of prostate cancer. Neither the editors nor the publisher accepts any responsibility for the accuracy of the information or consequences from the use or misuse of the information contained on this website.

Prostate Cancer May Result from Chronic Inflammation

April 8, 2002 /Johns Hopkins/ The earliest stages of prostate cancer may develop in lesions generally associated with chronic inflammation and might be reversible with anti-inflammatory drugs and dietary supplements, new research suggests.

Hopkins Kimmel Cancer Center researchers screened several stages of normal and cancerous prostate cells for changes in a key gene, called glutathione S-transferase p (GSTP1).

Glutathione S-transferase p (GSTP1) detoxifies environmental carcinogens and protects against cancer. In prostate cancer, this gene is deactivated through a biochemical process known as hypermethylatio

Methylation acts like the safety on a gun, causing a gene to stop working. Too much or "hyper"methylation on the GSTP1 gene shuts off its cancer-preventing properties as the prostate stops producing critical protective enzymes.

Hopkins Kimmel Cancer Center researchers looked at GSTP1 hypermethylation in normal and prostate cancers tissue samples as well as in inflammatory prostate lesions known as PIA (proliferative inflammatory atrophy) and PIN (prostate intraepithelial neoplasia).

They found GSTP1 methylation in three of 17 (17.6 percent) of PIA lesions, six of ten (60 percent) of high-grade PIN lesions and seven of seven (100 percent) prostate cancers. No GSTP1 methylation was detected in seven samples of normal prostate tissue.

The increasing levels of GSTP1 methylation may show how prostate cancer develops. The starting point may be PIA lesions, which are associated with inflammation and produce high levels of the GSTP1 gene suggesting that the gene has kicked into high gear from some kind of environmental stress. It is in these PIA lesions that researchers believe the first genetic mistakes are made leading to hypermethylation of the GSTP1 gene leaving prostate cells unable to repair damage from carcinogens.

With an onslaught of carcinogens from the environment and diet, researchers believe more gene mistakes are made, making PIA lesions progress to PIN lesions, funny-looking cells strongly linked to cancer and considered by some to be pre-cancerous.

Investigators will test the prostate cancer preventive effects of anti-inflammatory agents and antioxidant nutrients on PIA lesions in animal models.

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Recent News

Chronic Inflammation Linked With Start of Prostate Cancer: A 5 Year Follow Up Study April 2006

Benefit of PSA test, prostate cancer screening falls for older men Nov 25 2005

Sunshine protects men against prostate cancer June 2005

High-risk Prostate Cancer Can Be Predicted Without A Biopsy June 2005

Brothers at high risk for prostate cancer. Sept 2, 2004

PSA tests from age 35 needed to track or speed of rise; 2 points or more in one year suggests aggressive disease July 15, 2004

Men with "high grade PIN" are at risk for invasive prostate cancer, study finds Oct 19 2004

New drug aimed at men diagnosed with High Grade PIN Oct 19 2004

Common urinary tract virus linked to prostate cancer August 2004

Prostate cancer rate lower in men taking dutasteride for BPH Urology, Washington University School of Medicine, St. Louis (abstract) 04-10-15

Use of aspirin or other NSAIDs increases survival for men with prostate cancer. Oct 2004

Obesity Linked to More Aggressive Prostate Cancer Dec 23, 2003

Heavy Smoking Doubles Risk of Aggressive Prostate Cancer August 1, 2003.

Infections and cancer risk
"In the United States and other developed countries, approximately 7 per cent of all cancers have been linked to infections. In developing countries, this number reaches almost 25 percent." Harvard School of Public Health, 2003/2004

We subscribe to the HONcode principles.
Verify here.

This page last edited by J. Strax, Cecember 26, 2005.

Information on this website is not intended as medical advice nor to be taken as such. Consult qualified physicians specializing in the treatment of prostate cancer. Neither the editors nor the publisher accepts any responsibility for the accuracy of the information or consequences from the use or misuse of the information contained on this website.