Eating Well |
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Fats |
and Prostate Cancer |
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Compounds in fat affect hormones and cause chemical changes that may either protect against cancer or make tumors grow. Although many large population studies have not found links between total fat intake and increased risk for this cancer, researchers suspect that high fat diets may promote prostate, colorectal, pancreas, and breast cancer. For prostate cancer the risk arises because in men, fatty body tissue synthesizes small amounts of testosterone and related hormones. These play roles in fueling prostate cancer. In more detail, the influence of fat on prostaglandins and leukotrienes has been suggested as a mechanism by which dietary fats influence the start of cancer. Enzymes that metabolize arachicdonic acid are emerging as "significant mediators of growth stimulation" for epithelial cancers including prostate cancer. Polyunsaturated fatty acids may enhance tumor growth not only by promoting cell proliferation but also by suppressing apoptosis, the process by which, normally, damaged cells die off. So both the amount and the type of fat consumed may count. Animal research and some population studies suggest that polyunsaturated fats increase risk. Monounsaturated fats may be protective.
Hydrogenated and Partially Hydrogenated Fats This converts the fats into trans-fatty acids, which are used in margerine and vegetable shortening, bakery products, peanut butter and snack foods. Trans-fatty acids are thought to be bad for the heart and may also be a factor in prostate cancer. Olive Oil |
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