Protoxin, also called PRX302, is a drug being tested on men with localized recurrent prostate cancer in Phase I clinical trials in Texas and Vermont.

Patients considering this trial must have experienced recurrence after completing a full course of definitive external beam radiation or definitive brachytherapy (but not both) as primary therapy for diagnosed prostate cancer at least one year prior to enrollment

Our main news about Protoxin is here:
PSA-activated protoxin that kills prostate cancer: phase I clinical trial is underway
http://www.psa-rising.com/prostatecancer/protoxin1106.htm

A reader asked for a simpler, clearer explanation of what’s going on with this drug. Here’s what we know at the moment:

In Texas, one trial enrolled the first patients in May this year and is hoping to recruit 36 men with localized recurrent prostate cancer. Patients must have recurred after EBR or brachytherapy, have PSA level less than 20 ng/mL and PSA doubling time longer than 3 months. They must NOT be taking hormone drugs. Also, they must NOT have signs of metastatic disease including no bone metastases on bone scan, or any lymph node, lung, liver or soft tissue.
(full story…)

Phenoxodiol’s fast track status at FDA generates a lot on interest among men with advanced prostate cancer. But despite evidence that Phenoxodiol delays progression in hormone refractory prostate cancer, is the fast track to FDA approval petering out?
(full story…)

An Australian man has died after swallowing 10,000 times the daily dose of selenium, reports The Age online newspaper. The 75-year-old mistakenly “purchased sodium selenite powder used primarily as a supplement for livestock, swallowing 10 grams.”

The man’s case is reported was reported October 2 in the Medical Journal of Australia (”Accidental death from acute selenium poisoning“).

According to The Age, Australian doctors who treated the 75-year-old “have used his death to highlight the dangers of promoting complementary medicines without adequate instructions.” The doctors blame the internet.

Selenium for human consumption, as sold in pharmacies, health stores and supermarkets , typically comes in 200 microgram (µg) pills or capsules, which may be printed “200 mcg.”
(full story…)