Cycles of Cell Death, Proliferation Key to Liver Cancer
Liver cancer is likely caused by cycles of liver cell death and renewal, according to research at the University of California, San Diego (UCSD) School of Medicine.
The research, to appear online the week of June 19 in advance of publication in the journal Proceedings of the National Academy of Sciences, underscores the importance of JNK1-mediated cell death and compensatory proliferation. The findings by Michael Karin, Ph.D., professor pharmacology in UCSD’s Laboratory of Gene Regulation and Signal Transduction, and colleagues strongly suggest that the control of tissue renewal through the IKK and JNK pathways plays a key role in liver cancer in mouse models.
The research team studied what precedes inflammation – liver cell damage caused by toxic chemicals, which sets in motion the inflammation process
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