"Blood from men who had undergone the low-fat group significantly reduced in vitro growth of LNCaP cells compared to Western diet serum."
May 18, 2005 Â A high-fat diet and sedentary lifestyle may predispose men to develop prostate cancer through changes in serum hormones and growth factors.
In a previous study, researchers from University of California, Los Angeles and Baltimpor, MA. showed that blood drawn from men who were limited to a low-fat diet and were exercising reduced serum-stimulated growth of prostate cancer cells ina dish.
At the American Urological Association annual meeting this past May, the same research team presented results of another study they designed to see whether a low-fat vs Western diet affects the blood supply's impact on prostate cancer growth. This study involved men with prostate cancer on watchful waiting.
They took 18 men with prostate cancer and randomized them to eat either a low-fat (15% calories from fat) or a regular Western (40% calories from fat) diet for 4-weeks. The men's fasting blood was drawn before and after the diet period, and measured for sex hormones, lipids, fatty acids, IGF-I and IGF binding proteins.
To make sure the men stuck to the assigned diet, all their meals were prepared at the UCLA Clinical Research Center, with close monitoring by a research dietician.
To assess the effect of the diet on prostate cancer growth, LNCaP cells were cultured in the laboratory and bathed in "before" and "after" serum drawn from these 2 groups of 9 men each.
Results
Blood from men who had undergone the low-fat group significantly reduced in vitro growth of LNCaP cells compared to Western diet serum.
Serum levels of linoleic acid (omega-6, the predominant fatty acid in the Western diet in baked and fried food) were significantly reduced in the low-fat relative to the Western diet group and positively correlated with serum-stimulated growth.
In addition, serum omega-3 fatty acid levels (found in fish oil, predominant in the Asian diet) negatively correlated with serum-stimulated growth.
There was a trend for serum IGFBP-1 levels to negatively correlate with serum-stimulated growth in the low-fat group.
Conclusions
In this prospective randomized dietary intervention trial, a low-fat diet resulted in changes in serum fatty acid levels that impacted the growth of human LNCaP cancer cells in a dish.
Further studies are indicated evaluating reducing linoleic acid intake and increasing omega-3 fatty acid intake for prostate cancer prevention and treatment.
GROWTH INHIBITORY EFFECTS OF A LOW-FAT DIET ON PROSTATE CANCER CELLS IN VITRO: RESULTS OF A PROSPECTIVE RANDOMIZED DIETARY INTERVENTION TRIAL IN MEN WITH PROSTATE CANCER
William J Aronson*, Los Angeles, CA; Stephen J Freedland, Baltimore, MD; Francisco Conde, Naoko Kobayashi, Pinchas Cohen, Tung Ngo, Pak Leung, Susan Bowerman, Jenny Hong, Brandon Varr, Patricia deMiranda, David Elashoff, John Glaspy, Susanne Henning, David Heber, R James Barnard, Los Angeles, CA. Abstract
This page reported by J. Strax, last updated May 18, 2005
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