Overall gain in survival from Provenge immunotherapy (sipuleucel-T) is best for men who start on it with lower PSA

November 26, 2012

Lead author Gerald Chodak writes: "Although not adequately powered for significance, the results of this analysis support a consistent OS benefit with sipuleucel-T across PSA quartiles. The greater magnitude of benefit in pts with lower baseline PSA suggests that patients with less advanced disease may benefit more from treatment with sipuleucel-T. Baseline PSA (ng/mL)." (Source: ASCO, J Clin Oncol 30, 2012 (suppl; abstr 4648).

Overall survival (OS) benefit with sipuleucel-T by baseline PSA: An exploratory analysis from the phase III IMPACT trial.

Provenge survival and baseline PSA Chodak 2012



Dr. Nima SharifiNew Pathway to Potential Therapies for Advanced Prostate Cancer

27 July 2011 Involves DHT synthesis and "an alternative route that bypasses T and requires steroid 5a-reductase isoenzyme-1 (SRD5A1).

 

Related: A clinical trial is planned at Dana Farber Cancer Center to test dutasteride Avodart) plus abiraterone acetate (Zytiga) for metastatic castration-resistant prostate cancer.

Immunotherapy for Advanced Prostate Cancer

Dendreon Announces Expanded Production of Provenge Immunotherapy for Prostate Cancer

February 15, 2011

Robot-Assisted & Laparoscopic Surgery

Prostate surgeon with robotic equipmentHow does a robotic prostatectomy work?

Posted by J. Strax

February 15, 2011



Douglas Scherr M.D.Obesity as a Factor in Prostate Cancer Treatment Options

By Douglas Scherr, M. D.

November 6, 2009

 

Minimally Invasive Radical Prostatectomy Shows Advantages, But Also Certain Complications

Shorter and Safer Hospital Stays But More Risk of Incontinence and Erectile Dysfunction, Study Shows

JAMA Oct 14, 2009

Two Robots Better Than One for Prostate Surgery, Hopkins Urologists Say - Second Robot May Help Surgeon Preserve Erectile Nerves

April 26, 2009

Anti-Cancer Vaccine updates

FDA Approves PROVENGE ® for the Treatment of Men with Advanced Prostate Cancer

Cholesterol Controls

Anti-Cholesterol Statins May Yield Triple Benefits for Men's Prostate and Sexual Health

Sunday, 26 April 2009

Low Cholesterol May Cut Risk for High-grade Prostate Cancer


Low "Good" (HDL) Cholesterol May Be a Sign of Undiagnosed Cancer

November 4, 2009

Clinical Trials News

CyberKnife Radiosurgery for Organ-Confined Prostate Cancer : Homogenous Dose Distribution

Sponsor: Accuray Incorporated at 21 study centers for Patients with:

Low: CS T1b-T2a and Gleason 2-6 and PSA = 10, or Intermediate: CS T2b and Gleason 2-6 and PSA = 10 or CS T1b-T2b, and Gleason 2-6 and PSA = 20 ng/ml or Gleason 7 and PSA = 10 ng/ml. Prostate volume: = 100 cc

A Phase 1/11 Study of MDV3100(in JAPAN)

To Evaluate Safety, Tolerability, Pharmacokinetics and Efficacy of in Prostate Cancer Patients. For patients with progressive disease after prior androgen deprivation therapy. One arm of the trial is for patients who have had up to 2 prior chemothereapies, of which 1 chemo was Taxotere (docetaxel).

Phase III Randomized Study of Oral MDV3100 versus placebo in Chemotherapy-Naive Patients With Progressive Metastatic Prostate Cancer

At 39 medical study centers -- USA, Australia, Belgium, Canada, France, Sweden, UK, international center

Backgrounder on this drug in MedNews section, link below:--

New Targeted Therapy for Advanced Prostate, MDV3100, Safe and Effective in Initial, Phase I Trial

"Phase 3 clinical trial has begun to examine MDV3100 versus a placebo for the treatment of men with advanced prostate cancer who were previously treated with chemotherapy." Thursday April 15, 2010


Genetic Marker Found for Aggressive Prostate Cancer

Tuesday January 12, 2010

Feeling Like Myself Again After Cancer

By DANA JENNINGS New York Times January 12, 2010

 

Provenge Trial Ongoing & Recruiting At 8 US Centers — Open Label Study of Sipuleucel-T (Provenge) Immunotherapy for Men with Metastatic Prostate Cancer, All Participants Receive the Vaccine

Tokai Pharmaceuticals Initiates ARMOR Clinical Development Program for TOK-001; First Ever Multi-Target Investigational Drug for Prostate Cancer

November 12, 2009

Korean Company Announces Start of US Phase III Trials for Udenafil, Erectile Dysfunction Drug Under Development

Regina Holliday paints cancer muralMural for a Cancer Patient Tells a Story of Broken Healthcare

Regina Holliday has painted a 50 foot mural on a gas station wall in Washington D.C. depicting her husband Fred's struggle with broken health care while he was fighting stage IV kidney cancer at age 39. Read more....

November 9, 2009

Radiation Therapy

Hypofractionated radiation for higher-risk prostate cancer - it's convenient, requires fewer sessions. Is it safe and effective? Two study results from ASTRO annual meeting say it's promising:

Shorter Radiation Course Stops Cancer Growth in High-risk Prostate Cancer Patients (Italy)

Short Course High-Dose Radiation (IMRT) Looks Safe and Effective for Higher-Risk Prostate Cancer (USA)

Obama Orders Medical Marijuana Use Allowed Where State Law Makes it Legal

New guidelines order federal drug agents to stop arresting or charging patients, caregivers or suppliers who are dispensing, buying or using marijuana for medical purposes allowed by state law.

FDA Wants More Info From Amgen on Prolia™ (Denosumab) for Use Against Post-Menopausal Osteoporosis

Read Amgen company press release October 19, 2009

MRI Guided Biopsy to Find "Hidden" Prostate Tumors

October 9, 2009

Celebrex before Radical Prostate Surgery Not Effective, Study Finds

October 5, 2009

Fish Plus Veggie Diet Beats Pure Vegetarianism for Cancer Prevention

posted Oct 4, 2009

In Memoriam -- Rick Ward: Pioneer Prostate Cancer Activist

September 23 2009

New Genetic Variants Linked with Risk of Prostate Cancer

21 September 2009

Heavy Drinking Raises Risk of Aggressive Prostate Cancer and Cancels Preventive Effects of Proscar

August 15, 2009

PSA Velocity May be Irrelevant in Detection of Prostate Cancer

"Although there is a statistical association between prostate-specific antigen (PSA) velocity and prostate cancer, PSA velocity does not help detect prostate cancer once PSA and age are taken into consideration" -- Peter Scardino M.D. and team. Posted September 12, 2009

Older Prostate Cancer Patients' Chances of Surviving on Non-Invasive Treatment Improved Since in 1990s, Study Finds

In Screening Era, More Elderly Men Have Survived Prostate Cancer on "Watchful Waiting" (Active Surveillance)

Hormonal Deprivation in Prostate Cancer Treatment

"Androgen Deprivation Syndrome" - New Way of Looking At Side Effects of A Widely Used Therapy for Prostate Cancer

April 30 2009

Combined Androgen Blockade For Metastatic Prostate Cancer

Dr. Gerald Chodak MD talks about Prostate Cancer Therapy Using Combined Androgen Blockade. Click to go to page with his video.
video by Dr. Gerald Chodak
First posted September 17, 2009.

 

Prostate Test Going Ahead, Hopkins Scientist Says. Lawsuit "For Money"

September 10, 2009

Dr. Robert H. GetzenbergCompany Sues Cancer Scientist for Fraud, Says EPCA-2 Prostate Test Never Worked

September 10, 2009


Virus Link Found to Some Prostate Cancers

September 7, 2009

Diesel truck spewing smoke from unfiltered chimneysDiesel Exhaust Linked to Cancer Via New Blood Vessel Growth

September 1-3, 2009

More Blog Entries

Weight Gain Timing Affects Prostate Cancer Risk: Patterns Differ by Ethnic Group

September 1, 2009

Preventing Prostate Cancer

Two ZD4054 clinical trials for hormone refractory prostate cancer

August 28 2009

Hormone Therapy Riskier for Prostate Cancer Patients With Heart Conditions

August 26 2009

Increased Cancer Risks For Hispanics Who Move to USA

August 6 2009

Screening & Active Surveillance

 
 

FEATURED STORIES

Richard WassersugComing Out As a Eunuch After a Diagnosis of Prostate Cancer

BY RICHARD WASSERSUG

Prostate Cancer & Masculinity

Charles "Chuck" Maack Despite my loss of libido/potency/erection capability, in strength and power I am still just as much a man. Read on ...

By Chuck Maack. Sunday, November 23, 2008

Penile Rehabilitation after Prostatectomy


Chicago urologist Dr. Gerald Chodak launches videos for men faced with prostate cancer. Watch his talk on penile rehab after prostatectomy. Read more.

Real Men Get Prostate Cancer

First Evidence that Viagra May Shield the Heart from Damage from High Blood Pressure

 

Family History of Prostate Cancer Does Not Affect Brachytherapy Outcomes January 2, 2009

Cough Medicine Ingredient, Noscapine, Could Treat Prostate Cancer, Study Shows January 2, 2009

Dentist Links Fosamax-type Drugs to Jaw Necrosis January 1, 2009

Fosamax Linked to Esophageal Cancer

December 2008

COMMENT: "I would like to suggest an alternative for men (and women) to consider instead of bisphosphonates: Strontium." Herb S.

CT Scans: Most Doctors Lack Knowledge of Radiation Exposure Risks

April 24, 2009

January 5, 2009

 

Hormonal Therapy News


VA Hospital Botches Prostate Treatments

21 June 2009

Disparities in cancer care reflect hospital resources, U-M study finds

20 Aug 2009

PROVENGE Significantly Prolongs Survival for Men with Advanced Prostate Cancer in Pivotal Phase 3 IMPACT Study

Tuesday April 28, 2009

More Mixed Signals About "Lockerbie Bomber" Megrahi's Prostate Cancer

Lockerbie Bomber Megrahi Hospitalized for Prostate Cancer (Video)

September 9, 2009

RECENTLY

Cancer Vaccine Plus Interleukin-7 Boosts Immune Response to Cancer

Sunday, 26 April 2009

Michigan's Medical Marijuana Law Goes Into Effect

April 24, 2009

MRI Guided Biopsy: Effective Tool for Staging Prostate Cancer

April 23, 2009

New Method of Teaching Immune System to Recognize PSMA Prostate Cancer Marker Vaccine trial, Phase 1, ongoing in Rhode Island for advanced prostate cancer patients April 20, 2009

Gene Fusion Discovery May Lead to Improved Prostate Cancer Test

April 14, 2009

CureVac Receives FDA Approval to Start Phase I/IIa mRNA Vaccine Clinical Trial in Prostate Cancer January 5, 2009