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Broccoli Extracts May Fight Prostate Cancer, Pittsburgh Researcher Says

BroccoliDec. 22, 2003, –In the United States, only 1 out of 5 adults eat the recommended five or more fruits and vegetables per day. Fruits and vegetables are good for overall health, and a newly funded study may show that certain vegetables, such as broccoli, also offer protection against prostate cancer. UPCI researcher Shivendra Singh, Ph.D., has received a $1.7 million grant from the National Cancer Institute to study this vegetable for prostate cancer prevention.

"Clearly, what we eat has an effect on the development of diseases such as cancer," said Dr. Shivendra Singh, professor of pharmacology and urology at the University of Pittsburgh School of Medicine. "However, we know little about the mechanisms by which certain edible plants like broccoli help our bodies fight prostate cancer and other diseases. Our goal with this study is to better understand the function and relationship of substances in broccoli that appear to be linked to inhibiting prostate cancer growth."

Phytochemicals called isothiocyanates (ITCs), which are generated in broccoli and other vegetables when they are chewed. ITCs significantly reduces the risk for prostate cancer, studies suggest.

Dr. Singh's laboratory has found that some naturally occurring ITCs are highly effective in suppressing the growth of human prostate cancer cells at concentrations that are achievable through dietary intake of cruciferous vegetables such as watercress and broccoli.

In his current study, Dr. Singh seeks to find out more about how ITCs induce apoptosis, or cancer cell death. He hopes to gain insight into the key structural relationships between ITCs and cell processes and to identify potential biomarkers that could be useful for future intervention trials involving ITCs.

"The knowledge we gain from this study will help guide us in formulating practical and effective nutritional strategies for the prevention and treatment of prostate cancer," said Dr. Singh. In addition to studies involving broccoli, Dr. Singh also is examining the effect of garlic on prostate cancer prevention.

Follow-up: DIM: Vegetables that prevent some cancers may eventually yield cures, Texas researcher says January 2004

"Plastic" Trans Fats Wreak Havoc in the Body, Found in Many Popular Foods (Sept 2003)

Update: Food Manufacturers Oppose Trans Fat Consumer Information on Labels (Oct 9, 20003)

Green Tea's Cancer Fighting Allure becomes More Potent (August 5 2003).

Farmed Salmon High in PCBs Aug 2003

Ocean Salmon Dump PCBs in Spawning Waters Nature, 18 September 2003.

Eating Fatty Fish May Slash Risk Of Prostate Cancer June, 2001, Eating f fatty fish such as salmon, sardines, herring and mackerel could reduce the risk of prostate cancer by a third, according to a report in June 2 issue of The Lancet.
Full story

Super-Broccoli Bred to Fight CancerMay 25 2000. This cross between garden broccoli and a wild Sicilian variety is the latest veggie to hold out anti-cancer promise. The team that developed super-broccoli at the John Innes Centre at the Institute of Food Research in Norwich, England now have two commercial partners. Full story

Heart-Healthy Soy Labels May Help Prostate Cancer Survivors Men dealing with prostate cancer and people concerned about heart disease may be interested in eating soy foods -- but they discourage treating soy as a medicine or drug.

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