Category: Hormonal

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A small randomized Phase II study for men with progressive castrate-resistant prostate cancer has tested the effects of taking one-fourth the standard dose of Zytiga (abiraterone acetate) after a low-fat breakfast instead of standard dose on an empty stomach.

Taking one-fourth the standard dose with a low-fat breakfast, the study found, can be as effective – and four times less expensive – as taking the standard dose as recommended: on an empty stomach. The finding has significant financial implications.

Abiraterone acetate is a standard treatment for metastatic CRPC. Retail cost is about $8000 per month.

A group of doctors led by Russell Szmulewitz, MD, assistant professor of medicine at the University of Chicago and a specialist in medical treatment of patients with advanced prostate cancer, observed that "despite a large food effect (about a 17-fold increase in CMax with a high-fat meal), abiraterone acetate was administered under fasting conditions in its pivotal trials." ...continue reading "Low-dose Zytiga (abiraterone acetate) with a low-fat breakfast as effective as full dose on an empty stomach, study finds"

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June 2, 2015. Primary androgen deprivation therapy for localized prostate cancer increases diabetes risk by up to 60 per cent, particularly in men under 70 years of age, according to research published in the June issue of The Journal of Urology.

"As the benefits of primary androgen deprivation therapy for localized prostate cancer are controversial," the authors say, "and most prostate cancer survivors are of advanced age with comorbidities, it is important to determine if primary androgen deprivation therapy increases the risk of diabetes and to determine the susceptibility factors." ...continue reading "Diabetes A Risk For Men Treated With Androgen Deprivation for Localized Prostate Cancer"

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(TORONTO, Canada – Jan. 24, 2012) – For men diagnosed with low-risk, localized prostate cancer, treatment with dutasteride (brand name “Avodart”) delays disease progression, a 3-year study has found. The drug is classed as a 5a-reductase inhibitor. In men opting at this stage for "Active Surveillance," Avodart delayed the start of more active treatment while reducing anxiety.

...continue reading "Avodart Delays Low-Risk Prostate Cancer Progression, Study Finds"

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Posted April 16, 2005. Adding androgen-suppressing drugs to radiation therapy improves chances or long-term survival for men with high-risk prostate cancer

...continue reading "Androgen Deprivation Boosts Survival After Radiation for High Risk Prostate Cancer"