Category: High Risk

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Cancer cells' genetic pathways show which patients are likely to develop aggressive types of the disease

Sept. 7, 2016 -- Scientists at Cedars-Sinai have developed a new way to identify which prostate cancer patients are likely to develop aggressive types of the disease even if their tumors at first appear to be lower risk. The new findings could help physicians prescribe the most effective treatments for each patient based on how genes are activated in the individual tumor.

These findings raise the possibility that by determining the gene expression profile of a patient's tumor, physicians may be able to identify aggressive disease at the outset of diagnosis and start treatment earlier," said Sungyong You, PhD, an instructor in the Cedars-Sinai Department of Surgery and the first author of the study.

Sunyong You, PhD
Sunyong You, PhD uses computational, laboratory and genomics methods to learn more about the molecular mechanisms that promote lethal prostate cancer.

...continue reading "New tumor analysis method identifies high-risk prostate cancer"

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September 6, 2016. A study by investigators at Brigham and Women's Hospital (BWH) finds that a rise in prostate-specific antigen (PSA) levels in healthy men who have previously been treated for prostate cancer is significantly associated with a 1.6-fold increased risk of death. The team also studied men with prostate cancer who had another illness such as a history of heart attack or stroke, and did not find that PSA failure was predictive of the risk of death in these men.

The new work suggests that it's especially important for healthy men to be given information about the early results of available clinical trials that have been shown to reduce PSA failure, according to the study's authors. ...continue reading "PSA failure predicts risk of death only in healthy men"

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May help determine specialized treatment

PSA Rising via TORONTO, Canada – May 27, 2015 – Prostate cancer researchers in Canada have drawn a molecular portrait that provides the first complete picture of localized, multi-focal disease within the prostate and also unveils a new gene subgroup driving it.

...continue reading "Gene Subgroup C-MYC in Aggressive Gleason 7 Prostate Cancer"

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April 23, 2015. African American men have the highest rates of prostate cancer incidence and mortality in the United States. For the past twenty years cancer researchers have worried about this and researched various causal factors. Now a large study suggests obesity may play an important role in what specialists in disparities in prostate cancer risk are calling the "African-American race effect.

...continue reading "Obesity Significantly Increases Prostate Cancer Risk in African-American Men"