Category: Genetics

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Cancer cells' genetic pathways show which patients are likely to develop aggressive types of the disease

Sept. 7, 2016 -- Scientists at Cedars-Sinai have developed a new way to identify which prostate cancer patients are likely to develop aggressive types of the disease even if their tumors at first appear to be lower risk. The new findings could help physicians prescribe the most effective treatments for each patient based on how genes are activated in the individual tumor.

These findings raise the possibility that by determining the gene expression profile of a patient's tumor, physicians may be able to identify aggressive disease at the outset of diagnosis and start treatment earlier," said Sungyong You, PhD, an instructor in the Cedars-Sinai Department of Surgery and the first author of the study.

Sunyong You, PhD
Sunyong You, PhD uses computational, laboratory and genomics methods to learn more about the molecular mechanisms that promote lethal prostate cancer.

...continue reading "New tumor analysis method identifies high-risk prostate cancer"

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May help determine specialized treatment

PSA Rising via TORONTO, Canada – May 27, 2015 – Prostate cancer researchers in Canada have drawn a molecular portrait that provides the first complete picture of localized, multi-focal disease within the prostate and also unveils a new gene subgroup driving it.

...continue reading "Gene Subgroup C-MYC in Aggressive Gleason 7 Prostate Cancer"

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Dr Leszek Kotula, co-author of the WAVE1 study, explains in this video from 2013  how basic science research in his lab at Upstate Medical University in Syracuse, NY will benefit prostate cancer patients with better diagnostic and treatment options.

April 7, 2015. Researchers at Upstate Medical University, NY and Harvard University have linked the loss of key gene, WAVE1, to a lethal form of prostate cancer. They found that  in patients who were treated for prostate cancer, alterations in the WAVE1 gene were associated with a shorter remission.

...continue reading "Loss of WAVE1 gene linked to lethal prostate cancer"