In people with cancer angiogenesis involves the growth of tiny new blood vessels to generate a blood supply for tumors. This process has been shown to play an important role in the growth, proliferation and spread of prostate cancer tumors.

Vascular endothelial growth factor (VEGF) is a chemical signal produced by cells that stimulates the growth of new blood vessels. VEGF Inhibitors are a class of therapies that target the VEGF chemical pathway, aiming to prevent angiogenisis and tumor vascularization.

An article in Curr Mol Pharmacol. discusses this “major angiogenic signaling pathway involving VEGF in prostate cancer progression and the role of various promising agents that target this pathway.”