Recent stories on bisphosphonate side effects might be signaling the advent of a new, superior drug, but will Halozyme’s rHuPH20 enzyme solve the problem of jaw necrosis?

Drug development companies operate within the overall consumer culture. We all want better drugs, better everything. Generic Fosamax (alendronate) now costs just $4 at Wal-Mart, Kroger and other retail pharmacies. What might make right now a better than usual time to get word out to the masses that Fosamax carries some dreadful, if quite rare, risks?

Diane Wysowski of the FDA’s division of drug risk assessment says researchers should check into potential links between oral bisphosphonate drugs and cancer of the esophagus.

Merck’s oral osteoporosis drug Fosamax may carry a risk for esophageal cancer, Wysowski writes in a letter to January 1, 2009 New England Journal of Medicine.